{"id":4091,"date":"2019-10-25T14:05:38","date_gmt":"2019-10-25T07:05:38","guid":{"rendered":"https:\/\/jovarq.com\/?p=4091"},"modified":"2019-11-02T10:38:19","modified_gmt":"2019-11-02T03:38:19","slug":"thu-hoi-thuoc-chua-ranitidin-tren-toan-cau-vi-nhiem-tap-chat-gay-ung-thu","status":"publish","type":"post","link":"https:\/\/jovarq.com\/thu-hoi-thuoc-chua-ranitidin-tren-toan-cau-vi-nhiem-tap-chat-gay-ung-thu\/","title":{"rendered":"THU H\u1ed2I THU\u1ed0C CH\u1ee8A RANITIDIN TR\u00caN TO\u00c0N C\u1ea6U V\u00cc NHI\u1ec4M T\u1ea0P CH\u1ea4T G\u00c2Y UNG TH\u01af"},"content":{"rendered":"

THU H\u1ed2I THU\u1ed0C CH\u1ee8A RANITIDIN TR\u00caN TO\u00c0N C\u1ea6U V\u00cc NHI\u1ec4M T\u1ea0P CH\u1ea4T G\u00c2Y UNG TH\u01af<\/strong><\/span><\/p>\n

Ranitidin<\/strong> thu\u1ed9c nh\u00f3m thu\u1ed1c : <\/strong>\u0110\u1ed1i kh\u00e1ng th\u1ee5 th\u1ec3 H2 histamin.<\/span><\/p>\n

D\u1ea1ng thu\u1ed1c v\u00e0 h\u00e0m l\u01b0\u1ee3ng<\/strong><\/span><\/p>\n

D\u1ea1ng Ranitidin hydroclorid.<\/span><\/p>\n

Vi\u00ean nang: 150 mg, 300 mg.<\/span><\/p>\n

Dung d\u1ecbch u\u1ed1ng 75 mg\/5 ml; g\u00f3i b\u1ed9t 150 mg.<\/span><\/p>\n

Vi\u00ean n\u00e9n: 25 mg, 75 mg, 150 mg, 300 mg.<\/span><\/p>\n

Vi\u00ean s\u1ee7i b\u1ecdt: 150 mg, 300 mg.<\/span><\/p>\n

Thu\u1ed1c ti\u00eam 25 mg\/ml (2 ml, 6 ml, 40 ml).<\/span><\/p>\n

D\u01b0\u1ee3c l\u00fd v\u00e0 c\u01a1 ch\u1ebf t\u00e1c d\u1ee5ng<\/strong><\/span><\/p>\n

Ranitidin l\u00e0 m\u1ed9t thu\u1ed1c \u0111\u1ed1i kh\u00e1ng th\u1ee5 th\u1ec3 H2 histamin c\u00f3 c\u01a1 ch\u1ebf t\u00e1c d\u1ee5ng \u1ee9c ch\u1ebf c\u1ea1nh tranh v\u1edbi histamin \u1edf c\u00e1c th\u1ee5 th\u1ec3 H2 c\u1ee7a t\u1ebf b\u00e0o th\u00e0nh d\u1ea1 d\u00e0y, l\u00e0m gi\u1ea3m l\u01b0\u1ee3ng acid d\u1ea1 d\u00e0y ti\u1ebft ra c\u1ea3 ng\u00e0y v\u00e0 \u0111\u00eam trong \u0111i\u1ec1u ki\u1ec7n c\u01a1 b\u1ea3n v\u00e0 c\u1ea3 trong t\u00ecnh tr\u1ea1ng b\u1ecb k\u00edch th\u00edch b\u1edfi th\u1ee9c \u0103n, insulin, acid amin, histamin ho\u1eb7c pentagastrin. Ranitidin c\u00f3 t\u00e1c d\u1ee5ng \u1ee9c ch\u1ebf ti\u1ebft acid d\u1ea1 d\u00e0y m\u1ea1nh h\u01a1n cimetidin g\u1ea5p 3 – 13 l\u1ea7n. Ranitidin c\u00f3 th\u1ec3 b\u1ea3o v\u1ec7 ni\u00eam m\u1ea1c d\u1ea1 d\u00e0y ch\u1ed1ng ch\u1ea3y m\u00e1u v\u00e0 t\u00e1c d\u1ee5ng k\u00edch th\u00edch c\u1ee7a m\u1ed9t s\u1ed1 thu\u1ed1c (th\u00ed d\u1ee5 aspirin, thu\u1ed1c ch\u1ed1ng vi\u00eam kh\u00f4ng steroid).<\/span><\/p>\n

Ch\u1ec9 \u0111\u1ecbnh<\/strong><\/span><\/p>\n

\u0110i\u1ec1u tr\u1ecb lo\u00e9t d\u1ea1 d\u00e0y – t\u00e1 tr\u00e0ng.<\/span><\/p>\n

Tr\u00e0o ng\u01b0\u1ee3c d\u1ea1 d\u00e0y – th\u1ef1c qu\u1ea3n.<\/span><\/p>\n

H\u1ed9i ch\u1ee9ng Zollinger – Ellison.<\/span><\/p>\n

Lo\u00e9t do stress \u1edf \u0111\u01b0\u1eddng ti\u00eau h\u00f3a tr\u00ean.<\/span><\/p>\n

\u0110\u1ec1 ph\u00f2ng nguy c\u01a1 s\u1eb7c acid trong qu\u00e1 tr\u00ecnh g\u00e2y m\u00ea.<\/span><\/p>\n

Ch\u1ee9ng kh\u00f3 ti\u00eau.<\/span><\/p>\n

Ch\u1ed1ng ch\u1ec9 \u0111\u1ecbnh<\/strong><\/span><\/p>\n

Qu\u00e1 m\u1eabn v\u1edbi ranitidin ho\u1eb7c b\u1ea5t k\u1ef3 th\u00e0nh ph\u1ea7n n\u00e0o c\u1ee7a ch\u1ebf ph\u1ea9m<\/span><\/p>\n

Ng\u00e0y 02\/10\/2019, C\u1ee5c Qu\u1ea3n l\u00fd D\u01b0\u1ee3c \u0111\u00e3 c\u00f3 c\u00f4ng v\u0103n s\u1ed1 16814\/QLD-CL th\u00f4ng b\u00e1o thu h\u1ed3i m\u1ed9t s\u1ed1 thu\u1ed1c ch\u1ee9a ranitidin nhi\u1ec5m t\u1ea1p ch\u1ea5t, trong \u0111\u00f3 c\u00f3 bi\u1ec7t d\u01b0\u1ee3c g\u1ed1c Zantac<\/strong><\/span><\/p>\n

C\u0103n c\u1ee9 th\u00f4ng b\u00e1o c\u1ee7a C\u01a1 quan Khoa h\u1ecdc y t\u1ebf Singapore (HSA), C\u01a1 quan qu\u1ea3n l\u00fd d\u01b0\u1ee3c ph\u1ea9m Th\u1ee5y S\u0129 (Swissmedic) v\u1ec1 vi\u1ec7c thu h\u1ed3i c\u00e1c thu\u1ed1c ch\u1ee9a Ranitidine do ph\u00e1t hi\u1ec7n ch\u1ee9a t\u1ea1p ch\u1ea5t N-nitrosodimethylamine (NDMA) c\u00f3 nguy c\u01a1 g\u00e2y ung th\u01b0 \u1edf h\u00e0m l\u01b0\u1ee3ng v\u01b0\u1ee3t qu\u00e1 ng\u01b0\u1ee1ng cho ph\u00e9p c\u1ee7a qu\u1ed1c t\u1ebf. \u0110\u00ea \u0111\u1ea3m b\u1ea3o an to\u00e0n cho ng\u01b0\u1eddi s\u1eed d\u1ee5ng, C\u1ee5c Qu\u1ea3n l\u00fd D\u01b0\u1ee3c y\u00eau c\u1ea7u:<\/span><\/p>\n

    \n
  1. Thu h\u1ed3i t\u1ea5t c\u1ea3 c\u00e1c thu\u1ed1c th\u00e0nh ph\u1ea5m c\u00f3 t\u00ean sau \u0111\u00e2y:<\/span><\/li>\n
  2. Aciloc 150 (S\u0110K: VN17188-13) ch\u1ee9a Ranitidine (d\u01b0\u1edbi d\u1ea1ng Ranitidine HC1) 150 mg Vi\u00ean n\u00e9n bao phim c\u1ee7a Cadila Pharmaceuticals Ltd, India<\/span><\/li>\n
  3. Aciloc 300 (S\u0110K: VN17848-14) ch\u1ee9a Ranitidine (d\u01b0\u1edbi d\u1ea1ng Ranitidine HC1) 300 mg Vi\u00ean n\u00e9n bao phim c\u1ee7a Cadila Pharmaceuticals Ltd, India<\/span><\/li>\n
  4. Apo-Ranitidine 150 mg (S\u0110K: VN-3366- 07) ch\u1ee9a Ranitidine (d\u01b0\u1edbi d\u1ea1ng Ranitidine HC1) 150 mg Vi\u00ean n\u00e9n c\u1ee7a Apotex Inc., Canada<\/span><\/li>\n
  5. Zantac Tablets (S\u0110K: VN10264-10; VN20764-17) ch\u1ee9a Ranitidine HC1 t\u01b0\u01a1ng \u0111\u01b0\u01a1ng Ranitidine 150 mg Vi\u00ean n\u00e9n bao phim c\u1ee7a Glaxo Wellcome S.A., Spain<\/span><\/li>\n
  6. Zantac Injection (S\u0110K: VN10265-10; VN20516-17) ch\u1ee9a Ranitidine HC1 t\u01b0\u01a1ng \u0111\u01b0\u01a1ng Ranitidine 25 mg\/ml Dung d\u1ecbch ti\u00eam c\u1ee7a GlaxoSmithKline Manu\u00edacturing S.p.A., Italy<\/span><\/li>\n
  7. Ratylno-150 (S\u0110K: VN18567-14) (T\u00ean t\u1ea1i Singapore: Zynol150Tablet 150 mg) ch\u1ee9a Ranitidine 150 mg Vi\u00ean n\u00e9n bao phim c\u1ee7a Micro Labs Ltd, India<\/span><\/li>\n
  8. Hyzan Tablet 150 mg ch\u1ee9a Ranitidine 150 mg Vi\u00ean n\u00e9n bao phim Xepa-Soul Pattinson (Malaysia) Sdn Bhd, Malaysia<\/span><\/li>\n
  9. Neoceptin R-150 Tablet 150 mg ch\u1ee9a Ranitidine 150 mg Vi\u00ean n\u00e9n bao phim c\u1ee7a Beximco Pharmaceuticals Ltd<\/span><\/li>\n
  10. Vesyca film coated tablet 150mg ch\u1ee9a Ranitidine 150 mg Vi\u00ean n\u00e9n bao phim Y.s.p. Industries (M) Sdn. Bhd,. Malaysia<\/span><\/li>\n
  11. Xanidine Tablet 150 mg ch\u1ee9a Ranitidine 150 mg Vi\u00ean n\u00e9n bao phim c\u1ee7a Berlin Pharmaceutical Industry Co Ltd, Thailand<\/span><\/li>\n
  12. Zantac Syrup 150 mg\/10 ml ch\u1ee9a Ranitidine 150 mg\/ 10 rnl Si r\u00f4 c\u1ee7a Aspen Bad Oldesloe GmbH, Germany Glaxo Wellcome Operations<\/span> \n

    \"\"Tr\u01b0\u1edbc \u0111\u00f3, C\u1ee5c Qu\u1ea3n l\u00fd D\u01b0\u1ee3c c\u0169ng \u0111\u00e3 c\u00f3 c\u00f4ng v\u0103n s\u1ed1 16813\/QLD-CL ( c\u00f9ng ng\u00e0y 02\/10\/2019)<\/strong> y\u00eau c\u1ea7u c\u00e1c c\u01a1 s\u1edf s\u1ea3n xu\u1ea5t thu\u1ed1c ch\u1ee9a d\u01b0\u1ee3c ch\u1ea5t Ranitidine ch\u1ec9 \u0111\u01b0\u1ee3c \u0111\u01b0a v\u00e0o s\u1ea3n xu\u1ea5t thu\u1ed1c c\u00e1c l\u00f4 nguy\u00ean li\u1ec7u d\u01b0\u1ee3c ch\u1ea5t Ranitidine kh\u00f4ng c\u00f3 t\u1ea1p ch\u1ea5t NDMA. Tr\u01b0\u1eddng h\u1ee3p l\u00f4 nguy\u00ean li\u1ec7u d\u01b0\u1ee3c ch\u1ea5t Ranitidine c\u00f3 t\u1ea1p ch\u1ea5t NDMA th\u00ec kh\u00f4ng \u0111\u01b0\u1ee3c v\u01b0\u1ee3t qu\u00e1 gi\u1edbi h\u1ea1n cho ph\u00e9p c\u1ee7a t\u1ea1p ch\u1ea5t NDMA theo gi\u1edbi h\u1ea1n ch\u1ea5p nh\u1eadn quy \u0111\u1ecbnh t\u1ea1i ICH M7.<\/span><\/p>\n

    C\u1ee5 th\u1ec3: Gi\u1edbi h\u1ea1n NDMA t\u1ea1m th\u1eddi ch\u1ea5p nh\u1eadn kh\u00f4ng qu\u00e1 0.32 ppm (t\u00ednh tr\u00ean li\u1ec1u ch\u1ea5p nh\u1eadn t\u1ed1i \u0111a c\u1ee7a NDMA l\u00e0 96 nanogram\/ng\u00e0y v\u00e0 li\u1ec1u s\u1eed d\u1ee5ng t\u1ed1i \u0111a c\u1ee7a Ranitidine l\u00e0 300mg\/ng\u00e0y).<\/span><\/p>\n

    \u0110\u1ed3ng th\u1eddi, th\u1ef1c hi\u1ec7n \u0111\u00e1nh gi\u00e1 v\u00e0 ki\u1ec3m so\u00e1t ch\u1eb7t ch\u1ebd c\u01a1 s\u1edf cung \u1ee9ng nguy\u00ean li\u1ec7u, ngu\u1ed3n g\u1ed1c nguy\u00ean li\u1ec7u. Ki\u1ec3m tra ch\u1ea5t l\u01b0\u1ee3ng t\u1eebng l\u00f4 nguy\u00ean li\u1ec7u d\u01b0\u1ee3c ch\u1ea5t Ranitidine theo quy \u0111\u1ecbnh v\u00e0 ph\u00e2n t\u00edch b\u1ed5 sung ch\u1ec9 ti\u00eau \u0111\u1ed1i v\u1edbi t\u1ea1p ch\u1ea5t NDMA.<\/span><\/p>\n

    Ng\u1eebng l\u01b0u h\u00e0nh thu\u1ed1c tr\u00ean to\u00e0n c\u1ea7u<\/strong><\/span><\/p>\n

    Sau khi C\u01a1 quan Th\u1ef1c ph\u1ea9m v\u00e0 D\u01b0\u1ee3c ph\u1ea9m M\u1ef9 (FDA) t\u00ecm th\u1ea5y c\u00e1c t\u1ea1p ch\u1ea5t N-nitrosodimethylamine (NDMA) c\u00f3 nguy c\u01a1 g\u00e2y ung th\u01b0 \u1edf h\u00e0m l\u01b0\u1ee3ng v\u01b0\u1ee3t qu\u00e1 ng\u01b0\u1ee1ng cho ph\u00e9p.<\/span><\/p>\n

    Nh\u00e0 s\u1ea3n xu\u1ea5t thu\u1ed1c Th\u1ee5y S\u0129 Novartis \u0111\u00e3 ng\u1eebng ph\u00e2n ph\u1ed1i to\u00e0n c\u1ea7u c\u00e1c lo\u1ea1i thu\u1ed1c Ranitidine v\u00e0o th\u00e1ng tr\u01b0\u1edbc.<\/span><\/p>\n

    Tu\u1ea7n tr\u01b0\u1edbc, c\u00e1c chu\u1ed7i nh\u00e0 thu\u1ed1c thu\u1ed9c t\u1eadp \u0111o\u00e0n Walmart g\u1ed3m CVS Health Corp, Walgreen Boots Alliance Inc v\u00e0 Rite Aid Corp \u0111\u00e3 ng\u1eebng b\u00e1n c\u00e1c lo\u1ea1i thu\u1ed1c tr\u1ecb ch\u1ee9ng \u1ee3 n\u00f3ng kh\u00f4ng k\u00ea \u0111\u01a1n c\u00f3 ch\u1ee9a ranitidine.<\/span><\/p>\n

    C\u01a1 quan y t\u1ebf c\u1ee7a Canada \u0111\u00e3 y\u00eau c\u1ea7u c\u00e1c nh\u00e0 s\u1ea3n xu\u1ea5t thu\u1ed1c ng\u1eebng ph\u00e2n ph\u1ed1i lo\u1ea1i thu\u1ed1c n\u00e0y trong l\u00fac ch\u1edd \u0111\u1ee3i thu th\u1eadp th\u00eam th\u00f4ng tin. Th\u00e1ng tr\u01b0\u1edbc, c\u00e1c c\u01a1 quan qu\u1ea3n l\u00fd \u1edf H\u1ed3ng C\u00f4ng (Trung Qu\u1ed1c) \u0111\u00e3 r\u00fat b\u1ed1n s\u1ea3n ph\u1ea9m c\u00f3 ch\u1ee9a Ranitidine. C\u00f2n t\u1ea1i Ireland, 13 s\u1ea3n ph\u1ea9m c\u00f3 ch\u1ee9a Ranitidine \u0111\u00e3 b\u1ecb thu h\u1ed3i.<\/span><\/p>\n

    Ng\u00e0y 8-10 H\u00e3ng d\u01b0\u1ee3c ph\u1ea9m GlaxoSmithKline (GSK) cho bi\u1ebft \u0111ang thu h\u1ed3i s\u1ea3n ph\u1ea9m Zantac, thu\u1ed1c ch\u1ed1ng \u1ee3 n\u00f3ng v\u00e0 c\u00e1c tri\u1ec7u ch\u1ee9ng li\u00ean quan t\u1edbi d\u1ea1 d\u00e0y ph\u1ed5 bi\u1ebfn \u1edf t\u1ea5t c\u1ea3 c\u00e1c th\u1ecb tr\u01b0\u1eddng tr\u00ean to\u00e0n c\u1ea7u.<\/span><\/p>\n

    N<\/strong>\u00a0-Nitrosodimethylamine<\/strong>\u00a0(\u00a0NDMA<\/strong>\u00a0) l\u00e0 m\u1ed9t\u00a0h\u00f3a ch\u1ea5t h\u1eefu c\u01a1<\/a>\u00a0d\u1ec5 bay h\u01a1i<\/a>\u00a0, \u0111\u01b0\u1ee3c s\u1ea3n xu\u1ea5t d\u01b0\u1edbi d\u1ea1ng s\u1ea3n ph\u1ea9m ph\u1ee5 c\u1ee7a m\u1ed9t s\u1ed1 quy tr\u00ecnh c\u00f4ng nghi\u1ec7p v\u00e0 hi\u1ec7n di\u1ec7n \u1edf m\u1ee9c r\u1ea5t th\u1ea5p trong m\u1ed9t s\u1ed1 th\u1ef1c ph\u1ea9m nh\u1ea5t \u0111\u1ecbnh, \u0111\u1eb7c bi\u1ec7t l\u00e0 nh\u1eefng th\u1ef1c hun kh\u00f3i .<\/span><\/p>\n

    NDMA tan trong n\u01b0\u1edbc, c\u00f3 m\u00e0u v\u00e0ng v\u00e0 \u00edt ho\u1eb7c kh\u00f4ng c\u00f3 m\u00f9i v\u1ecb.\u00a0<\/span><\/p>\n

    N\u00f3 \u0111\u1ed9c h\u1ea1i cho gan v\u00e0 c\u00e1c c\u01a1 quan kh\u00e1c v\u00e0 l\u00e0\u00a0ch\u1ea5t g\u00e2y ung th\u01b0 \u1edf<\/a>\u00a0ng\u01b0\u1eddi.\u00a0N\u00f3 c\u0169ng \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng \u0111\u1ec3 t\u1ea1o ung th\u01b0 \u1edf chu\u1ed9t \u0111\u1ec3 nghi\u00ean c\u1ee9u ung th\u01b0.<\/span><\/p>\n

    Ngu\u1ed3n: Trung t\u00e2m DI & ADR Qu\u1ed1c gia<\/em><\/strong><\/span><\/p>\n

    Khoa d\u01b0\u1ee3c Tr\u01b0\u1eddng Cao \u0111\u1eb3ng Y d\u01b0\u1ee3c H\u00e0 n\u1ed9i –\u00a0t\u1ed5ng h\u1ee3p<\/em><\/strong><\/span><\/p>\n<\/li>\n<\/ol>\n

     <\/p>\n

     <\/p>\n","protected":false},"excerpt":{"rendered":"

    THU H\u1ed2I THU\u1ed0C CH\u1ee8A RANITIDIN TR\u00caN TO\u00c0N C\u1ea6U V\u00cc NHI\u1ec4M T\u1ea0P CH\u1ea4T G\u00c2Y UNG TH\u01af Ranitidin thu\u1ed9c nh\u00f3m thu\u1ed1c : \u0110\u1ed1i kh\u00e1ng th\u1ee5 th\u1ec3 H2 histamin. D\u1ea1ng thu\u1ed1c v\u00e0 h\u00e0m l\u01b0\u1ee3ng D\u1ea1ng Ranitidin hydroclorid. Vi\u00ean nang: 150 mg, 300 mg….<\/p>\n","protected":false},"author":8,"featured_media":4092,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"image","meta":{"footnotes":""},"categories":[3],"tags":[144],"class_list":["post-4091","post","type-post","status-publish","format-image","has-post-thumbnail","hentry","category-tin-tuc","tag-thu-hoi-thuoc-chua-ranitidin-tren-toan-cau-vi-nhiem-tap-chat-gay-ung-thu","post_format-post-format-image"],"yoast_head":"\nTHU H\u1ed2I THU\u1ed0C CH\u1ee8A RANITIDIN TR\u00caN TO\u00c0N C\u1ea6U V\u00cc NHI\u1ec4M T\u1ea0P CH\u1ea4T G\u00c2Y UNG TH\u01af - Tr\u01b0\u1eddng Cao \u0111\u1eb3ng Y D\u01b0\u1ee3c H\u00e0 N\u1ed9i<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/jovarq.com\/thu-hoi-thuoc-chua-ranitidin-tren-toan-cau-vi-nhiem-tap-chat-gay-ung-thu\/\" \/>\n<meta property=\"og:locale\" content=\"vi_VN\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"THU H\u1ed2I THU\u1ed0C CH\u1ee8A RANITIDIN TR\u00caN TO\u00c0N C\u1ea6U V\u00cc NHI\u1ec4M T\u1ea0P CH\u1ea4T G\u00c2Y UNG TH\u01af - Tr\u01b0\u1eddng Cao \u0111\u1eb3ng Y D\u01b0\u1ee3c H\u00e0 N\u1ed9i\" \/>\n<meta property=\"og:description\" content=\"THU H\u1ed2I THU\u1ed0C CH\u1ee8A RANITIDIN TR\u00caN TO\u00c0N C\u1ea6U V\u00cc NHI\u1ec4M T\u1ea0P CH\u1ea4T G\u00c2Y UNG TH\u01af Ranitidin thu\u1ed9c nh\u00f3m thu\u1ed1c : \u0110\u1ed1i kh\u00e1ng th\u1ee5 th\u1ec3 H2 histamin. D\u1ea1ng thu\u1ed1c v\u00e0 h\u00e0m l\u01b0\u1ee3ng D\u1ea1ng Ranitidin hydroclorid. 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